[ZeonOne]

This is a debatable topic.

Damage potential of a weapon with a right set of Skill is a big factor in this case.

If you want the strongest weapon in a single hit that causes the most damage possible, you should do melee. With melee, combine with a high str stat and high skill ranking, in theory, you would be able to do highet damage in the game.

Due to the high average damage, some people prefer an Axe. Or an blunt weapon, such as an whip for its critical hit and hit rate.